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SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
USERS' SCORE
Good
Based on 12 Reviews
8.8
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Significant relevance to heart protection
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
8
Zinc supplementation improves heart health
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.
Effectiveness of zinc assessed
We explored the connection between zinc supplementation and heart health, particularly in the context of obesity. Our research focused on how zinc affects cardiac remodeling, a process that can lead to serious heart issues when influenced by factors like high-fat diets. In our study, obese mice were examined after being fed a high-fat diet, allowing us to observe changes in their heart structures and inflammation levels.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Read More
8
Trace minerals and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
Moderate relevance to heart disease
We analyzed the relationship between trace mineral intake, specifically zinc, and the risk of coronary artery disease (CAD) in middle-aged and older adults. The participants, totaling 895 residents from Shika town in Japan, were selected carefully to exclude those with a genetic predisposition to high cholesterol levels.
Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.
While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.
Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.
While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.
Read More
Most Useful Reviews
9.5
Reduced cramps
This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.
Read More
9.5
Cured heart pain
Super! I have a small child, and lack of sleep was affecting my heart. Following my cardiologist's advice, I started taking Calcium, Magnesium, and Zinc. Since then, my heart pain has vanished. I highly recommend this preparation, though it can be hard to find; I'll definitely purchase it again. If my review was useful, please say “yes”.
Read More
9.5
Adjusted heart rate
I drank all 250 tablets. The effects were immediate; my heart rate stabilised, and my tachycardia disappeared. This product relieves stress and anxiety, and I now take it only as needed. I'm very satisfied with this drug.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
9
Zinc's role in cardiac protection
ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts.
Study emphasizes combined treatment effects
We explored the fascinating relationship between heart health, atrial natriuretic peptide (ANP), and zinc (Zn) in the context of ischemia/reperfusion (I/R) injury, a condition that occurs when blood supply returns to the heart after a period of being blocked. Our research utilized a range of models, including isolated heart experiments in rats and ANP knockout mice, along with clinical investigations involving plasma samples from 216 patients suffering from ischemia-related diseases.
During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.
Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.
Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
Read More
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Significant relevance to heart protection
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
8
Calcium scoring aids heart disease prevention
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
Moderate relevance to calcium treatment
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
8
Zinc supplementation improves heart health
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.
Effectiveness of zinc assessed
We explored the connection between zinc supplementation and heart health, particularly in the context of obesity. Our research focused on how zinc affects cardiac remodeling, a process that can lead to serious heart issues when influenced by factors like high-fat diets. In our study, obese mice were examined after being fed a high-fat diet, allowing us to observe changes in their heart structures and inflammation levels.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.8
9.5
Reduced cramps
This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.
Read More
9.5
Cured heart pain
Super! I have a small child, and lack of sleep was affecting my heart. Following my cardiologist's advice, I started taking Calcium, Magnesium, and Zinc. Since then, my heart pain has vanished. I highly recommend this preparation, though it can be hard to find; I'll definitely purchase it again. If my review was useful, please say “yes”.
Read More
9.5
Adjusted heart rate
I drank all 250 tablets. The effects were immediate; my heart rate stabilised, and my tachycardia disappeared. This product relieves stress and anxiety, and I now take it only as needed. I'm very satisfied with this drug.
9.5
Supported heart health
Good decision! I take magnesium to strengthen my heart muscle due to tachycardia and extrasystole. Since starting this, I’ve had only one attack. I'm pleased with the results.
9.5
Improved absorption
If you’re seeking a supplement complex, this is the best! Its special chelated form ensures maximum absorption. Calcium maintains bone strength, magnesium distributes calcium, and zinc aids collagen production. I bought it for my parents, and it significantly helped my father with his post-heart attack cramps and my mother’s night cramps. Don’t forget to take Vitamin D for enhanced absorption.
Read More
